Zhenpeng Qin

Assistant Professor - Mechanical Engineering
Tags: Mechanical Engineering

Professional Preparation

PhD - Mechanical Engineering
University of Minnesota, Twin Cities - 2014
MS - Mechanical Engineering
University of Akron - 2009
BS - Thermal and Power Engineering
Xi'an Jiaotong University - 2007

Research Areas

NanoThermal Bioenginering Laboratory

Biotransport and Nanotechnology, including

  • Fundamentals: Bio Heat and Mass Transfer, Thermo-Plasmonics, Optics
  • Diagnostics: Point-of-Care, Nano Biosensors, Immunoassay
  • Therapeutics: Nanomaterials, Nanomedicine, Cancer Nanotechnology

Our laboratory focuses on fundamental understanding of the bio-nano interface and translating this to biomedical applications. Current efforts focus on the thermo-plasmonic fundamentals and its effects at the interface between biological systems and nanomaterials. Specifically, experimental techniques and methods will be developed to understand the effects of nanoparticle plasmonic heating on proteins and other biomolecules immediately surrounding the nanoparticle. This leads to new enabling tools for fundamental research, and to applications in both diagnostic and therapeutic areas.

While developing technologies that will eventually translate into biomedical applications, we are also interested in tackling challenging problems from medical device and pharmaceutical industry with our unique set of knowledge and tools in the areas listed above. 

We are always looking for highly motivated individuals to join our laboratory. With the interdisciplinary nature of the work, candidates with different backgrounds (engineering, biology, chemistry etc) are welcome to apply. 

Publications

Boulware, D. R., Rolfes, M. A., Rajasingham, R., von Hohenberg, M., Qin, Z., Taseera, K., Schutz, C., Kwizera, R., Butler, E. K., Meintjes, G., Muzoora, C., Bischof, J. C. & Meya, D. B. Multisite Validation of Point-of-Care Cryptococcal Antigen Lateral Flow Assay and Quantification by Laser Thermal Contrast Measurement, Emerging Infectious Diseases, 20(1), 45-53 2014 - Publication
Jiang, C., Qin, Z. & Bischof, J. C. Membrane-Targeting Approaches for Enhanced Cancer Cell Destruction with Irreversible Electroporation, Annals of Biomedical Engineering, 42(1), 193-204 2014 - Publication
Qin, Z., Jiang, J., Long, G. & Bischof, J. C. Irreversible Electroporation: An in vivo Study With Dorsal Skin Fold Chamber, Annals of Biomedical Engineering, 41(3), 619-29 2013 - Publication
Qin, Z. & Bischof, J. C. Thermophysical and Biological Responses of Gold Nanoparticle Laser Heating,Chemical Society Review, 41, 1191-217 2012 - Publication
Qin, Z., Chan, W. C. W., Boulware, D. R., Akkin, T., Butler, E. K. & Bischof, J. C. Significantly Improved Analytical Sensitivity of Lateral Flow Immunoassays by Using Thermal Contrast. Angewandte Chemie International Edition, 51, 4358-61 2012 - Publication

Appointments

Doctoral Dissertation Fellow - University of Minnesota [2013–2014]
College of Science and Engineering
Interdisciplinary Doctoral Fellow - University of Minnesota [2012–2013]
Research Assistant - University of Minnesota [2009–2012]
Teaching Assistant - University of Akron [2007–2009]

Projects

SPIE talk 2011
2011–2011 Qin, Z., Etheridge, M. & Bischof, J. C. Nanoparticle Heating: Nanoscale to Bulk Effects of Electromagnetically Heated Iron Oxide and Gold for Biomedical Applications. SPIE – Photonics West, San Francisco, CA, 2011
NEMB talk 2014
2014–2014 Qin, Z., Randrianalisoa, J., Lipiski, W. & Bischof, J.C. Reconciling Theoretical Prediction and Experimental Measurement of Gold Nanoparticle Optical Properties for Biomedical Applications. ASME NanoEngineering for Medicine and Biology, San Francisco, CA, 2014 (Travel grant & finalist in Ph.D. poster competition)
STM talk 2014
2014–2014 Qin, Z., Balasubramanian, S. K., Wolkers, W. F., Pearce, J. A. & Bischof, J. C. Activation Energy As A System Specific Signature Of Thermal Protein Denaturation At Molecular And Cellular Scales. Society of Thermal Medicine 31st Annual Meeting, Minneapolis, MN, 2014
SBC talk 2012
2012–2012 Qin, Z., Akkin, T., Chan W. C. W. & Bischof, J. C., Thermal Analysis Measurement of Gold Nanoparticle Interactions with Cell and Biomaterials, ASME Summer Bioengineering Conference, Fajardo, PR, 2012 (Ph.D. competition award)
SBC talk 2010
2010–2010 Qin, Z. & Bischof, J. C. One Dimensional Experimental Setup to Study The Heating of Nanoparticle Laden Systems, ASME Summer Bioengineering Conference, Naples, FL, 2010

Additional Information

Selected Awards and Honors
  • Finalist, ASME NanoEngineering for Medicine and Biology (NEMB) Doctoral Poster Competition (2014)
  • Doctoral Dissertation Fellowship, University of Minnesota (2013)
  • Student Poster Award, Institute of Engineering in Medicine (IEM) Conference and Retreat, University of Minnesota (2013)
  • Interdisciplinary Doctoral Fellowship, University of Minnesota (2012)
  • Gates Foundation Travel Award, American Society of Tropical Medicine and Hygiene (2012)
  • 2nd Place in Doctoral Student Paper Competition, ASME Summer Bioengineering Conference (2012)
  • Department of Mechanical Engineering Fellowship, University of Minnesota (2009)
  • Excellent Student Award by Chinese Society of Theoretical and Applied Mechanics (2006)
  • Baosteel Education Foundation Fellowship (2005)
  • China General Guangdong Nuclear Power Group Fellowship (2004)
  • University Siyuan Fellowship(2004)
  • National Scholarship of China (2003)

News Articles

Researchers Receive UT System Grant to Investigate the Brain
Three UT Dallas researchers are among the first grant recipients of a new UT System initiative that aims to fuel interdisciplinary and pioneering research on the human brain.

Among the 158 proposals submitted to UT BRAIN (Brain Research through Advancing Innovative Neurotechnologies), 45 recipients from various UT System institutions were named, totaling $4.5 million in funding. The UT Dallas recipients are: Dr. Zhenpeng Qin and Dr. Jun Wang, both from the Erik Jonsson School of Engineering and Computer Science, and Dr. Greg Dussor from the School of Behavioral and Brain Sciences. Each will receive $100,000.
Drug Delivery to the Brain
Brain tumors are known to be lethal, with a median survival of about 14.6 months for a type of cancer called glioblastoma multiforme, according to the American Brain Tumor Association. One of the obstacles to delivering drugs to the brain is the presence of blood-brain barrier, which allows only certain materials to cross from the bloodstream into brain tissue.

“The blood-brain barrier is a sophisticated structure that gives an optimal environment for brain function but also severely limits the penetration of anti-cancer drugs,” Qin said. “The goal of our project is to develop a novel approach to open the blood-brain barrier and allow the access of a wide range of therapeutic drugs to brain tumor cells.”