Sheena D'Arcy

PhD - Structural Biology
University of Cambridge, UK - 2008

BS - Biochemistry and Biology
University of Sydney, Australia - 2003

Mechanistic conformational and substrate selectivity profiles emerging in the evolution of enzymes via parallel trajectories 2024 - Journal Article

TRAMP assembly alters the conformation and RNA binding of Mtr4 and Trf4-Air2 2024 - Other

Molecular basis of RanGTP-activated nucleosome assembly with Histones H2A-H2B bound to Importin-9 2023 - Other

Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex 2023 - Journal Article

Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex 2022 - Other

Hydrogen-deuterium exchange mass spectrometry of Mtr4 with diverse RNAs reveals substrate-dependent dynamics and interfaces in the arch 2022 - Journal Article

Leveraging intrinsic flexibility to engineer enhanced enzyme catalytic activity 2022 - Journal Article

Hydrogen-deuterium exchange mass spectrometry of Mtr4 with diverse RNAs reveals substrate-dependent dynamics and interfaces in the arch 2021 - Other

NIH Grant Enables Chemist To Unwrap DNA Mysteries

Dr. Sheena D’Arcy, assistant professor of chemistry in the School of Natural Sciences and Mathematics, recently received a Maximizing Investigators’ Research Award for Early Stage Investigators (ESI-MIRA) (grant number R35GM133751) from the National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health (NIH).

D’Arcy’s research focuses on the structure and function of the proteins that are involved in gene transcription — the process of “reading” DNA instructions to create the proteins that carry out life functions.