Zachary Campbell

Assistant Professor - Biological Sciences
Tags: Molecular Biology Cell Biology Biology Biochemistry and Biophysics

Research Areas

RNA-protein interactions
Translational control
Pain

Publications

Type I Interferons Act Directly on Nociceptors to Produce Pain Sensitization: Implications for Viral Infection-Induced Pain. 2020 - Journal Article
Conserved Expression of Nav1.7 and Nav1.8 Contribute to the Spontaneous and Thermally Evoked Excitability in IL-6 and NGF-Sensitized Adult Dorsal Root Ganglion Neurons In Vitro 2020 - Journal Article
Molecular entrapment by RNA: an emerging tool for disrupting protein-RNA interactions in vivo. 2020 - Journal Article
Shape-morphing living composites. 2020 - Journal Article
Intercellular Arc signaling regulates vasodilation 2020 - Other
Principles of mRNA control by human PUM proteins elucidated from multi-modal experiments and integrative data analysis. 2020 - Journal Article
A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity. 2019 - Journal Article
Differences between Dorsal Root and Trigeminal Ganglion Nociceptors in Mice Revealed by Translational Profiling. 2019 - Journal Article
RNA control in pain: Blame it on the messenger. 2019 - Journal Article
Type I interferons act directly on nociceptors to produce pain sensitization: Implications for viral infection-induced pain 2019 - Other

News Articles

Researchers Devise Decoy Molecule to Block Pain Where It Starts
For anyone who has accidentally injured themselves, Dr. Zachary Campbell not only sympathizes, he’s developing new ways to blunt pain.

“If you have ever hit yourself with a hammer, afterward, even a light touch can be painful for days or even weeks,” said Campbell, who researches pain on the molecular level at The University of Texas at Dallas. “While many of us may not be coordinated enough to avoid an accident, my goal is to disrupt the inception and persistence of pain memories."
A Scientific Dating Game: Biologists Play RNA-Protein Matchmakers

Virtually all functions in our bodies require precise interactions between radically different types of molecules. The vast majority of the time, these encounters yield nothing, but a special few sustain life as we know it.

Team Creates Shape-Changing Material That Pushes Biological Boundaries
Combining the powers of the living and the inanimate, an interdisciplinary team from The University of Texas at Dallas has embedded genetically modified yeast into a synthetic gel to create a novel, shape-changing material designed to grow under specific biochemical or physical conditions.

“This is definitely a case where the product is more than the sum of its parts,” said Taylor Ware MS’11, PhD’13, assistant professor of bioengineering in the Erik Jonsson School of Engineering and Computer Science and corresponding author of a paper published in January in Science Advances, the American Association for the Advancement of Science’s open-access journal.

The idea to use the reproductive growth of cells to drive shape change within an inanimate container began with an old, reliable standby: baker’s yeast, or Saccharomyces cerevisiae.

Funding

R01NS114018
~2,000,000 - NIH [2020/09–2024/09]
R01NS100788
~2,000,000 - NIH [2017/01–2021/01]
3’ End Regulation in Nociceptor Plasticity - PI
NCATS TR003149 UG1/UG3
~1,000,000 - NIH [2019/10–2021/10]
hiPSC-based DRG tissue mimics on multi-well electrodes MEAs -CoI
DMR NSF 1905511
~400,000 - NSF [2019/06–2021/06]
This project will examine genetically controlled polymers - CoPI