Zachary Campbell

Assistant Professor - Biological Sciences
Tags: Molecular Biology Cell Biology Biology Biochemistry and Biophysics

Research Areas

RNA-protein interactions
Translational control
Pain

Publications

A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity. 2019 - Journal Article
Differences between Dorsal Root and Trigeminal Ganglion Nociceptors in Mice Revealed by Translational Profiling. 2019 - Journal Article
RNA control in pain: Blame it on the messenger. 2019 - Journal Article
Engineering a conserved RNA regulatory protein repurposes its biological function in vivo. 2019 - Journal Article
Nociceptor translational profiling reveals the Ragulator-Rag GTPase complex as a critical generator of neuropathic pain. 2018 - Journal Article
Activation of the integrated stress response in nociceptors drives methylglyoxal-induced pain. 2018 - Journal Article
Adult mouse sensory neurons on microelectrode arrays exhibit increased spontaneous and stimulus-evoked activity in the presence of interleukin-6. 2018 - Journal Article
Global pairwise RNA interaction landscapes reveal core features of protein recognition. 2018 - Journal Article
Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice. 2018 - Journal Article
RNA-binding proteins as targets for pain therapeutics. 2018 - Journal Article

News Articles

Researchers Devise Decoy Molecule to Block Pain Where It Starts
For anyone who has accidentally injured themselves, Dr. Zachary Campbell not only sympathizes, he’s developing new ways to blunt pain.

“If you have ever hit yourself with a hammer, afterward, even a light touch can be painful for days or even weeks,” said Campbell, who researches pain on the molecular level at The University of Texas at Dallas. “While many of us may not be coordinated enough to avoid an accident, my goal is to disrupt the inception and persistence of pain memories."
A Scientific Dating Game: Biologists Play RNA-Protein Matchmakers

Virtually all functions in our bodies require precise interactions between radically different types of molecules. The vast majority of the time, these encounters yield nothing, but a special few sustain life as we know it.

Funding

R01NS100788
~2,000,000 - NIH [2017/01–2020/01]
3’ End Regulation in Nociceptor Plasticity - PI
NCATS TR003149 UG1/UG3
~1,000,000 - NIH [2019/10–2021/10]
hiPSC-based DRG tissue mimics on multi-well electrodes MEAs -CoI
DMR NSF 1905511
~400,000 - NSF [2019/06–2021/06]
This project will examine genetically controlled polymers - CoPI