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Xintong Dong

Xintong Dong

Assistant Professor - Biological Sciences

We study antimicrobial peptide signaling at host-microbe interfaces.

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Professional Preparation

Postdoc - Neuroscience
Johns Hopkins University - 2022
Ph.D. - Biology
Stanford University - 2016
B.S. - Biochemistry
University of Wisconsin - Madison - 2010

Research Areas

Antimicrobial peptide signaling in urinary tract infections
We are interested in how antimicrobial peptides contribute to urinary tract immunity by activating receptors on immune cells and sensory neurons.
Host-microbe interaction in the skin
We use mouse and bacterial genetics to understand how S. aureus interacts with antimicrobial peptides in the mammalian skin.
Neuro-immune crosstalk in psoriasis
We try to understand how defensins facilitate neuro-immune crosstalk and cause psoriatic itch.

Publications

Neuroimmune interactions between itch neurons and skin microbes 2025 - Journal Article
Antimicrobial Peptide Signaling in Skin Diseases 2025 - Journal Article
Fungal Defensins: Dual Roles in Itch and Inflammation 2025 - Journal Article
Fungal Defensins: Dual Roles in Itch and Inflammation 2024 - Journal Article
Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain 2022 - Journal Article
Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection 2022 - Journal Article
A basophil-neuronal axis promotes itch 2021 - Journal Article
A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity 2019 - Journal Article

Awards

R01 - NIDDK [2024]
Discovery Award - National Psoriasis Foundation [2023]
Leading Edge Fellow - Leading Edge Symposium [2020]
Damon Runyon/HHMI postdoc fellowship - Damon Runyon Cancer Research Foundation [2017]