Nicole De Nisco

Assistant Professor - Biological Sciences
Tags: Microbiology Molecular Biology Infectious Disease Cell Biology Immunology Pathobiology

Professional Preparation

Doctor of Philosophy - Molecular Biology
Massachusetts Institute of Technology - 2013
Bachelor of Science - Biology
Massachusetts Institute of Technology - 2007

Research Areas

Molecular basis of microbial pathogenesis and host response during recurrent urinary tract infection
Current research focuses recurrent urinary tract infection (RUTI) as part of an ongoing clinical collaboration with the Department of Urology at UT Southwestern Medical Center. Dr. De Nisco’s research combines access to clinical samples with techniques from fields of molecular microbiology, cell biology and immunology to discover how both microbe and host contribute to this disease. Examples of available research projects include: 1) characterizing the host inflammatory response during RUTI and elucidating its role in recurrence 2) deciphering the virulence mechanisms of clinically-relevant RUTI pathogens 3) understanding the impact of the urinary microbiome on UTI recurrence through metagenomics.


Global analysis of cell cycle gene expression of the legume symbiont Sinorhizobium meliloti 2014 - Journal Article
Host plant peptides elicit a transcriptional response to control the Sinorhizobium meliloti cell cycle during symbiosis 2014 - Journal Article
The DivJ, CbrA and PleC system controls DivK phosphorylation and symbiosis in Sinorhizobium meliloti 2013 - Journal Article
Sinorhizobium meliloti CpdR1 is critical for co-ordinating cell cycle progression and the symbiotic chronic infection 2009 - Journal Article

News Articles

Study Details Bacteria’s Role in Recurrent Urinary Tract Infections
A new finding by researchers at The University of Texas at Dallas and UT Southwestern Medical Center shows that several species of bacteria reside in bladder tissue of postmenopausal women who experience recurrent urinary tract infections (RUTIs).

The results, published online April 17 in the Journal of Molecular Biology, represent the first systematic analysis of biopsies from patients in this population. The findings provide a better understanding of the interaction between bacteria and host tissue, which might lead to more effective treatment strategies.

Urinary tract infections (UTIs) are irritating and painful, sometimes debilitatingly so. The majority of UTIs are caused by the bacterium Escherichia coli, which normally lives in human intestines but sometimes gets into the urinary tract, where it is not welcome.