Nicole De Nisco

Assistant Professor - Biological Sciences
Tags: Microbiology Molecular Biology Infectious Disease Cell Biology Immunology Pathobiology

Professional Preparation

Doctor of Philosophy - Molecular Biology
Massachusetts Institute of Technology - 2013
Bachelor of Science - Biology
Massachusetts Institute of Technology - 2007

Research Areas

Molecular basis of microbial pathogenesis and host response during recurrent urinary tract infection
Current research focuses recurrent urinary tract infection (RUTI) as part of an ongoing clinical collaboration with the Department of Urology at UT Southwestern Medical Center. Dr. De Nisco’s research combines access to clinical samples with techniques from fields of molecular microbiology, cell biology and immunology to discover how both microbe and host contribute to this disease. Examples of available research projects include: 1) characterizing the host inflammatory response during RUTI and elucidating its role in recurrence 2) deciphering the virulence mechanisms of clinically-relevant RUTI pathogens 3) understanding the impact of the urinary microbiome on UTI recurrence through metagenomics.

Publications

Natural Transformation in Vibrio parahaemolyticus: a Rapid Method To Create Genetic Deletions 2018 - Journal Article
The Biochemistry of Sensing: Enteric Pathogens Regulate Type III Secretion in Response to Environmental and Host Cues 2018 - Journal Article
The cytotoxic type 3 secretion system 1 ofVibriorewires host gene expression to subvert cell death and activate cell survival pathways 2017 - Journal Article
Science SignalingPodcast for 16 May 2017:Vibriorewires host cells 2017 - Journal Article
Cell Cycle Control by the Master Regulator CtrA in Sinorhizobium meliloti 2015 - Journal Article
Global analysis of cell cycle gene expression of the legume symbiont Sinorhizobium meliloti 2014 - Journal Article
Host plant peptides elicit a transcriptional response to control the Sinorhizobium meliloti cell cycle during symbiosis 2014 - Journal Article
The DivJ, CbrA and PleC system controls DivK phosphorylation and symbiosis in Sinorhizobium meliloti 2013 - Journal Article
Sinorhizobium meliloti CpdR1 is critical for co-ordinating cell cycle progression and the symbiotic chronic infection 2009 - Journal Article