Nicole De Nisco

Assistant Professor - Biological Sciences
Tags: Microbiology Molecular Biology Infectious Disease Cell Biology Immunology Pathobiology

Professional Preparation

Doctor of Philosophy - Molecular Biology
Massachusetts Institute of Technology - 2013
Bachelor of Science - Biology
Massachusetts Institute of Technology - 2007

Research Areas

Molecular basis of microbial pathogenesis and host response during recurrent urinary tract infection
Current research focuses recurrent urinary tract infection (RUTI) as part of an ongoing clinical collaboration with the Department of Urology at UT Southwestern Medical Center. Dr. De Nisco’s research combines access to clinical samples with techniques from fields of molecular microbiology, cell biology and immunology to discover how both microbe and host contribute to this disease. Examples of available research projects include: 1) characterizing the host inflammatory response during RUTI and elucidating its role in recurrence 2) deciphering the virulence mechanisms of clinically-relevant RUTI pathogens 3) understanding the impact of the urinary microbiome on UTI recurrence through metagenomics.

Publications

Complete Genome Sequences of Three Uropathogenic Klebsiella quasipneumoniae Strains Isolated from Postmenopausal Women with Recurrent Urinary Tract Infection 2021 - Journal Article
Manipulation of IRE1-Dependent MAPK Signaling by a Vibrio Agonist-Antagonist Effector Pair 2021 - Journal Article
Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women 2021 - Journal Article
Metal-Organic Framework Enhanced Cellular and Humoral Immune Response Against Sepsis Causing Infection 2020 - Journal Article
Manipulation of IRE1-dependent MAPK signaling by a Vibrio agonist-antagonist effector pair 2020 - Other
Complete Genome Sequences of Seven Uropathogenic Escherichia coli Strains Isolated from Postmenopausal Women with Recurrent Urinary Tract Infection 2020 - Journal Article
Advances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection 2020 - Journal Article
Detection of Tissue-resident Bacteria in Bladder Biopsies by 16S rRNA Fluorescence In Situ Hybridization 2019 - Journal Article
FIMBRIAE AND FLAGELLA MEDIATED SURFACE MOTILITY AND THE EFFECT OF GLUCOSE ON NONPATHOGENIC AND UROPATHOGENIC ESCHERICHIA COLI 2019 - Other
Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection. 2019 - Journal Article

News Articles

Study Details Bacteria’s Role in Recurrent Urinary Tract Infections
A new finding by researchers at The University of Texas at Dallas and UT Southwestern Medical Center shows that several species of bacteria reside in bladder tissue of postmenopausal women who experience recurrent urinary tract infections (RUTIs).

The results, published online April 17 in the Journal of Molecular Biology, represent the first systematic analysis of biopsies from patients in this population. The findings provide a better understanding of the interaction between bacteria and host tissue, which might lead to more effective treatment strategies.

Urinary tract infections (UTIs) are irritating and painful, sometimes debilitatingly so. The majority of UTIs are caused by the bacterium Escherichia coli, which normally lives in human intestines but sometimes gets into the urinary tract, where it is not welcome.

Funding

Glycosaminoglycan Utilization and Metabolism by the Microbiota of the Urogenital Tract
- The Welch Foundation [2020/06–2023/06]
Identifying urogenital microbiota that can degrade vaginal estrogen therapy in postmenopausal women
- The Foundation for Women's Wellness []