Chen J, Kim YC, Jung Y-C, Xuan Z, Dworkin G, Zhang Y, Zhang MQ, Wang SM (2008) Scanning the human genome at kilobase resolution. Genome Res. 18:751-62. 2008 - Publication
Wu Q, Kim YC, Lu J, Xuan Z, Chen J, Zheng Y, Zhou T, Zhang MQ, Wu C-I, Wang SM (2008) Poly ATranscripts Expressed in HeLa Cells, PLoS ONE, 3:e2803. 2008 - Publication
Zhao X, Yoon S, Zhang MQ, Ye K, Geschwind DH, Sebat J, Iakoucheva LM (2008) High Connectivity among Autism Gene Candidates in Biological Networks: Evidence for Common Pathways. Submitted. 2008 - Publication
Nahle Z, Hsieh M, Pietka T, Coburn CC, Grimaldi PA, Zhang MQ, Das D, Abumrad NA. (2008) CD36-dependent Regulation of Muscle FoxO1 and PDK4 in the PPARgamma/beta-mediated Adaptation to Metabolic Stress. J. Biol. Chem. 283:14317-26. 2008 - Publication
Eguchi J, Yan Q-W, Schones DE, Kamal M, Hsu C-H, Zhang MQ, Crawford GE, Rosen ED (2008) Identification of interferon-regulatory factors (IRFs) as regulators of adipocyte gene expression by mapping DNase hypersensitive sites during adipogenesis. Cell Metabolism. 7:86-94. 2008 - Publication
Zhang C, Li W-H, Krainer AR, Zhang MQ (2008) An RNA landscape of evolution for optimal exon and intron discrination. Proc. Acad. Natl Sci. USA, 105:5797-802. 2008 - Publication
Wang X, Xuan Z, Zhao X, Li Y and Zhang MQ (2008) High-resolution Human Core-promoter prediction with CoreBoost_HM. Genome Res. 22:2902. 2008 - Publication
Wang X, Gu J, Zhang MQ, Li Y (2008) Identification of phylogenetically conserved microRNA cisregulatory elements across 12 Drosophila species. 24:165-71. 2008 - Publication
Bernard D, Prasanth KV, Nakamura T, Xuan Z, Zhang MQ, Sedel F, Triller A, Spector DL, Bessis A (2008) A nuclear retained non-coding RNA regulates synaptogenesis. Submitted. 2008 - Publication
Wu X, Jiang R., Zhang MQ, Li S (2008) Large-scale network-based prediction of human disease genes. Mol. Sys. Biol. 4:189. 2008 - Publication
Researchers from the School of Natural Sciences and Mathematics
at The University of Texas at Dallas have teamed with colleagues at the UT Southwestern Children’s Medical Center Research Institute
to create a new method for understanding the causes of genetic diseases, such as sickle cell anemia and some cancers.
The new system allows researchers to define the molecular structures that control the activity of regulatory DNA sequences in the human genome. Dr. Michael Q. Zhang
and postdoctoral researcher Dr. Yong Chen from Zhang’s Computational Biology Laboratory
— along with assistant professor of biological sciences Dr. Zhenyu Xuan
— collaborated on the formulation of the system called CAPTURE, or CRISPR Affinity Purification in situ of Regulatory Elements. Their work was published in a recent issue of the journal Cell.
Doctoral student Peng Xie came to The University of Texas at Dallas primarily to follow his mentor, Dr. Michael Q. Zhang
, and his passion, computational biology.
In the three years he has been on campus, Xie has exemplified the multitude of reasons that promising graduate students come to UT Dallas — opportunity, support and career advancement.
Xie is a member of the first cohort of the Eugene McDermott Graduate Fellows Program
. In addition to a stipend, tuition and fees, and a research budget, the McDermott fellowship provides professional development and enrichment opportunities.
Dr. Michael Zhang, a leading scientist in computational biology and genomic research, has joined UT Dallas as professor and Cecil H. and Ida Green Distinguished Chair of Systems Biology Science. Zhang’s chaired position in the School of Natural Sciences and Mathematics begins establishment of a new Center for Systems Biology. “In attracting a researcher of the stature of Dr. Zhang to our faculty, we expect to nucleate a major effort in genomics and computational biology that focuses on the genetic underpinnings of disease,” said Myron Salamon, dean of the School of Natural Sciences and Mathematics. Computational biology bridges the life sciences and quantitative sciences – mathematics, statistics and computer science – to understand living systems.