Tang M.H., Varadan V., Kamalakaran S., Zhang M.Q., Dimitrova N., Hicks J. (2013) Major chromosomal breakpoint intervals in breast cancer co-localize with differentially methylated regions. Front Oncol. 2:197. PMID:23293768 2013 - Publication
Akerman M., Zhang M.Q., Krainer A. (2013) ProteoMirExpress: inferring microRNA-centered regulatory networks from high throughput proteomic and mRNA expression data. MCP, Submitted. 2013 - Publication
Megha Rajaram; Jianping Zhang; Tim Wang; Cem Kuscu; Mamoru Kato; Vladimir Grubor; Robert Weil; Asluag Helland; Anne-Lise Borrenson-Dale; Kathleen Cho; Douglas A Levine; Alan N Houghton; Jedd D Wolchok; Lois Myeroff; Sanford D Markowitz; Michael Zhang; Alex Krasnitz; Robert Lucito; David Mu; Scott Powers (2013) Two Distinct Categories of Focal Deletions in Cancer Genomes. PLoS ONE, submitted. 2013 - Publication
Wen-Yu Chung, Robert J. Schmitz, Tanya Biorac, Delia Ye, Miroslav Dudas, Gavin D. Meredith, Christopher C. Adams, Joseph R. Ecker and Michael Q. Zhang (2013) Constructing hepitypes: phasing local genotype and DNA methylation. JNSNE, In press. 2013 - Publication
Xie W., Schultz M., Lister R., Hou Z., Rajagopal N., Ray P., Whitaker J.W., Tiam S., Hawkins D.R., Leung D., Yang H., Wang T., Swanson S.A., Zhang J., Zhu Y., Lee A.Y., Kim A., Nery J., Urich M.A., Kuan S., Yen C., Klugman S., Yu P., Suknuntha K., Propson N.E., Chen H., Edsall L.E., Wagner U., Li Y., Ye Z., Kulkarni A., Xuan Z., Chung W., Chi N.C., Antosiewicz-Bourget J., Slukvin I., Stewart R., Zhang M.Q., Wang W., Thomson J.A., Eckert J.R., Ren B. (2013) Epigenomic Analysis of Multi-lineage Differentiation of Human Embryonic Stem Cells. Cell, In press. 2013 - Publication
Zhang Z., Ma X., Zhang M.Q. (2012) Bivalent-like chromatin markers are predictive for transcription start site distribution in human. PLoS ONE, 7:e38112. PMID:22768038. 2012 - Publication
Li R., Guo W., Gu J., Zhang M.Q., Wang X.W. (2012) Chromatin state and microRNA determine different gene expression dynamics responsive to TNF stimulation. Genomics. 100:297-302. PMID:22824656. 2012 - Publication
Sleumer M.C., Wei G., Wang Y., Chang H., Xu T., Chen R., Zhang M.Q. (2012) Regulatory elements of Caenorhabditis elegans ribosomal protein genes. BMC Genomics. 13:433. PMID:22401550. 2012 - Publication
Xing H.*, Mo Y., Liao W., Zhang M.Q.* (2012) Genomewide localization of protein-DNA binding and histone modification by BCP with ChIP-seq data. PLoS CB, 8:e1002613. PMID: 22844240. 2012 - Publication
Xing H., Liao W., Mo Y., Zhang M.Q. 2012 A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIP-seq Data Types. J Vis Exp, Dec 10;(70). doi:pii: 4273. 2012 - Publication
Researchers from the School of Natural Sciences and Mathematics
at The University of Texas at Dallas have teamed with colleagues at the UT Southwestern Children’s Medical Center Research Institute
to create a new method for understanding the causes of genetic diseases, such as sickle cell anemia and some cancers.
The new system allows researchers to define the molecular structures that control the activity of regulatory DNA sequences in the human genome. Dr. Michael Q. Zhang
and postdoctoral researcher Dr. Yong Chen from Zhang’s Computational Biology Laboratory
— along with assistant professor of biological sciences Dr. Zhenyu Xuan
— collaborated on the formulation of the system called CAPTURE, or CRISPR Affinity Purification in situ of Regulatory Elements. Their work was published in a recent issue of the journal Cell.
Doctoral student Peng Xie came to The University of Texas at Dallas primarily to follow his mentor, Dr. Michael Q. Zhang
, and his passion, computational biology.
In the three years he has been on campus, Xie has exemplified the multitude of reasons that promising graduate students come to UT Dallas — opportunity, support and career advancement.
Xie is a member of the first cohort of the Eugene McDermott Graduate Fellows Program
. In addition to a stipend, tuition and fees, and a research budget, the McDermott fellowship provides professional development and enrichment opportunities.
Dr. Michael Zhang, a leading scientist in computational biology and genomic research, has joined UT Dallas as professor and Cecil H. and Ida Green Distinguished Chair of Systems Biology Science. Zhang’s chaired position in the School of Natural Sciences and Mathematics begins establishment of a new Center for Systems Biology. “In attracting a researcher of the stature of Dr. Zhang to our faculty, we expect to nucleate a major effort in genomics and computational biology that focuses on the genetic underpinnings of disease,” said Myron Salamon, dean of the School of Natural Sciences and Mathematics. Computational biology bridges the life sciences and quantitative sciences – mathematics, statistics and computer science – to understand living systems.