Lloyd Lumata

Assistant Professor - Physics
Tags: Cancer Metabolism Physics MRI NMR Spectroscopy Biochemistry Hyperpolarized MRI

Professional Preparation

Postdoc - Biomedical Magnetic Resonance
UT Southwestern Medical Center - 2014
PhD - NMR Physics
National High Magnetic Field Laboratory at Florida State University - 2008
B.S. - Physics
Western Mindanao State University (Philippines) - 2002

Research Areas

Dynamic Nuclear Polarization (DNP) Instrumentation Development
we assemble instruments called DNP hyperpolarizer -- a physics-based technology that enhances the magnetic resonance imaging (MRI) signals by >10,000-fold.

see one of the instruments that we built: https://onlinelibrary.wiley.com/doi/full/10.1002/mrc.4624
DNP optimization
we optimize the DNP signals to obtain the highest possible MRI signal enhancements ranging from 10,000-50,000-fold or higher.

see: https://pubs.acs.org/doi/abs/10.1021/acs.jpclett.8b01687
Application of DNP technology to cancer metabolic imaging
we apply the super-enhanced MRI signals (>10,000-fold) for metabolic imaging of cancer and other pathologies with superb sensitivity and high specificity.

see review article: https://www.sciencedirect.com/science/article/pii/S0076687915002670

Publications

Modulation of CEST images in vivo by T 1 relaxation: A new approach in the design of responsive PARACEST agents 2013 - Journal Article
Dissolution DNP-NMR spectroscopy using galvinoxyl as a polarizing agent 2012 - Journal Article
1H and 195Pt NMR Study of the Parallel Two-Chain Compound Per2[Pt(mnt)2] 2012 - Journal Article
13C]Pyruvate Doped with Trityl OX063, BDPA, or 4-Oxo-TEMPO 2012 - Journal Article
Fast Dissolution Dynamic Nuclear Polarization NMR of 13C-Enriched 89Y-DOTA Complex: Experimental and Theoretical Considerations 2012 - Journal Article
Production and NMR characterization of hyperpolarized 107,109Ag complexes 2012 - Journal Article
The efficiency of DPPH as a polarising agent for DNP-NMR spectroscopy 2012 - Journal Article
Inside Cover: Production and NMR Characterization of Hyperpolarized 107,109Ag Complexes (Angew. Chem. Int. Ed. 2/2012) 2011 - Journal Article
Production and NMR Characterization of Hyperpolarized 107,109Ag Complexes 2011 - Journal Article
BDPA: An Efficient Polarizing Agent for Fast Dissolution Dynamic Nuclear Polarization NMR Spectroscopy 2011 - Journal Article

Appointments

Advisory council member
National High Magnetic Field Laboratory [2017–2019]
Users advisory committee member of the Electron Magnetic Resonance (EMR) program of the National High Magnetic Field Laboratory (NHMFL) in Tallahassee, FL
Chair
Institutional Biosafety and Chemical Safety Committee at UT Dallas [2017–2019]
reviews the biosafety and chemical safety aspects of research protocols at UT Dallas.
Chair
UTD Physics Renfrow Scholarship Committee [2017–2019]
reviews applications for travel and research-related graduate scholarship of physics students.

Awards

Frisco ISD Independent Study and Mentorship (Mentor) - Frisco ISD [2017]
FSU Program for Instructional Excellence (PIE) Award - Florida State University [2007]

Projects

DNP Instrumentation and Hyperpolarized Magnetic Resonance Imaging (MRI) of Aberrant Cancer Metabolism
2014/06 Our lab's main research is focused on hyperpolarized magnetic resonance: instrumentation, physics, optimization methods and biomedical applications (specifically, aberrant cellular metabolism in cancer). Hyperpolarization, technically dynamic nuclear polarization (DNP), is a physics technique wherein we create a high degree of non-Boltzmann distribution of insensitive nuclear spins at low temperature and high magnetic field via microwave irradiation of free electrons. Our goal is to get the highest enhanced nuclear polarization possible for insensitive nuclear spins such as 13C, 15N, 89Y, 107,109Ag etc. by optimizing the physical parameters at cryogenic conditions (close to 1K). We then utilize a fast dissolution device that converts the frozen hyperpolarized samples at cryogenic conditions into hyperpolarized liquids at physiologically tolerable temperatures. What this means is that the NMR and MRI signals of reporter molecules (NMR/MRI molecular probes that can detect pH, metabolism, and other important biological activities) are enhanced by 10,000-100,000-fold! We aim to explore and investigate new hyperpolarized NMR and MRI biosensors to improve medical diagnostics

Presentations

see the complete list at: https://dnpnmr.weebly.com/presentations.html

News Articles

Researchers Receive $4.5 Million in Funding for Cancer Projects
Dr. Lloyd Lumata, assistant professor of physics, will use his $200,000 CPRIT grant to develop a new noninvasive imaging technique that could detect glioblastoma earlier and more accurately. The technique uses hyperpolarization technology to boost by more than 10,000-fold the sensitivity of MRI signals from key biological molecules associated with glioblastoma.

In addition to mapping cancer in the brain more precisely, the technology could reduce the need for patient exposure to X-rays from CT scans and radioactive imaging tracers, or for removal of brain tissue for diagnosis.

Funding

Ultrasensitive Detection of Altered Biochemistry in Brain Cancer via Hyperpolarized 13C Magnetic Resonance
$250,000.00 - Welch Foundation [2018/06–2021/05]
Grant Number AT-1877-20180324
Hyperpolarized 89Y MRI of Cancer
$250,000.00 - UTD Collaborative Biomedical Research Award (CoBRA) [2019/07–2021/06]
Hyperpolarized 89Y MRI of extracellular milieu of tumors
Hyperpolarized 13C MRI of glioblastoma
$200,000.00 - Cancer Prevention and Research Institute of Texas [2018/09–2020/08]
Award No. RP180716
Hyperpolarized 13C MRI of Kidney Cancer
114,750.00 - US Department of Defense [2019/09–2020/08]
metabolic imaging of clear cell renal cell carcinoma using hyperpolarized 13C MRI
Non-Invasive Diagnostic Assessment of Lung Cancer Using Hyperpolarized 13C Serine
$153,000.00 - US Department of Defense [2017/08–2019/07]
Award No. W81XWH-17-1-0303