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Ph.D. - Molecular Pathology-Lipid Sciences Wake Forest University School of Medicine
M.S. - Occupational Health and Toxicology Fudan University
B.S - Preventive Medicine Fudan University
Our long-term research interest is to identify critical mediators and important pathways that contribute to the development of advanced liver damage (both alcoholic and non-alcoholic) and associated metabolic disorders, including insulin resistance and chronic inflammation.
Dietary cholesterol in alcohol-associated liver disease 2023 - publications
PPARγ in Vagal Sensory Neurons Regulates Energy Balance. 2014 - publications
Instructor University of Texas Southwestern Medical Center at Dallas [2017–2020]
Alcohol-associated liver disease (AALD)
Alcohol-associated liver disease (AALD) is one of the major causes of chronic liver disease and has become a serious health problem worldwide. Currently, we are interested in exploring the following aspects: 1) the tissue-specific role of de novo lipogenesis; 2) the role of gut-liver axis; 3) the involvement of lipolysis controlled by sympathetic nervous system and 4) dietary factors.
Obesity-associated fatty liver disease and insulin resistance
My previous work has demonstrated that hepatocyte toll-like receptor 4 (TLR4) plays critical roles in regulating obesity-associated inflammation, insulin resistance and fatty liver disease. I have generated and characterized two novel mouse models, which allows deletion and re-expression of TLR4 in a tissue-specific manner. These valuable tools will be used to evaluate the contribution of vagal afferent TLR4 in obesity-induced impairments in liver function and glucose homeostasis.
Role of Hepatocyte TLR4 in Alcohol-Induced Steatohepatitis and Insulin Resistance
- NIH/NIAAA [2017/06–2022/05]
K01 (Mentored Research Scientist Career Development Award)
Role of Dietary Cholesterol in Alcoholic Steatohepatitis and Insulin Resistance