Sven Kroener

Associate Professor - Behavioral and Brain Sciences
 
972-883-2039
BSB10514
Faculty Page
ORCID
Tags: Cognition and Neuroscience

Professional Preparation

Ph.D. - Psychology
Ruhr-University Bochum, Germany - 2000
M.A. - Psychology
Ruhr-University Bochum, Germany - 1996

Research Areas

Drug addiction
Mechanisms of substance abuse of alcohol and cocaine.

Publications

Deletion of the Mitochondrial Matrix Protein CyclophilinD Prevents Parvalbumin Interneuron Dysfunctionand Cognitive Deficits in a Mouse Model of NMDA Hypofunction 2020 - Journal Article
Deletion of the mitochondrial matrix protein cyclophilin-D prevents parvalbumin interneuron dysfunction and cognitive deficits in a mouse model of NMDA hypofunction 2020 - Other
Delay-Period Activity and Executive Functions of the Prefrontal Cortex 2019 - Journal Article
Vagus nerve stimulation during extinction learning reduces conditioned place preference and context-induced reinstatement of cocaine seeking 2019 - Journal Article
Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease 2019 - Journal Article
Neuropathic pain creates an enduring prefrontal cortex dysfunction corrected by the type II diabetic drug metformin but not by gabapentin 2018 - Journal Article
Calcium chloride mimics the effects of acamprosate on cognitive deficits in chronic alcohol-exposed mice 2018 - Journal Article
Antioxidant Treatment in Male Mice Prevents Mitochondrial and Synaptic Changes in an NMDA Receptor Dysfunction Model of Schizophrenia 2017 - Journal Article
Vagus nerve stimulation reduces cocaine seeking and alters plasticity in the extinction network 2017 - Journal Article
Antioxidant Treatment with N-acetyl Cysteine Prevents the Development of Cognitive and Social Behavioral Deficits that Result from Perinatal Ketamine Treatment 2017 - Journal Article

Additional Information

PERSONAL STATEMENT
My lab studies the neuronal circuitry of the prefrontal cortex (PFC) and how alterations in synaptic transmission are related to behavioral problems in drug addiction.

Pathological dysfunctions that disrupt the intrinsic circuitry of the PFC and impair so-called "executive functions" and behavioral flexibility have been implicated in numerous mental illnesses, including schizophrenia and drug addiction.
Current projects in my laboratory examine how drugs of abuse (specifically cocaine and alcohol) can alter PFC function. We use an animal model of alcohol addiction to study changes in glutamatergic synaptic transmission and NMDA receptor function in the PFC. Chronic ethanol exposure induces homeostatic increases in NMDA receptors, which alters synaptic plasticity, contributing to a loss of response inhibition during the development and maintenance of addiction to alcohol.
A second line of work uses vagus nerve stimulation (VNS) as a tool to increase extinction from drug seeking and to prevent relapse.
All of our projects use a combination of behavioral, electrophysiological, and immunohistochemical techniques. 

News Articles

Nerve Therapy Study Finds Potential Way to Reduce Drug Cravings
A new preclinical study led by a University of Texas at Dallas researcher shows that vagus nerve stimulation (VNS) therapy might have the potential to help people overcome drug addiction by helping them learn new behaviors to replace those associated with seeking drugs.

The new research, published in the January issue of the journal Learning and Memory, found that drug cravings in addicted rats were reduced when they were treated with VNS. It’s possible that the research could be applied to people who have been addicted to drugs, said senior author Dr. Sven Kroener, assistant professor in the School of Behavioral and Brain Sciences.
Provost Award Recognizes Faculty Who Inspire Future Researchers
For Dr. Sven Kroener, assistant professor at the School of Behavioral and Brain Sciences, teaching science is more than showing a student how to use a microscope or defining a GABAergic neuron.
“Science is not just data acquisition,” Kroener said. “It’s analysis and asking, ‘Did it do something to my bar graphs? Did it alter my group averages?,’ and then communicating it. If you can put together figures and then make a paper, only then is it science.”
National Funding Will Support Research on Treatment for Anxiety
Two professors in the School of Behavioral and Brain Sciences  recently received national funding to study the mechanisms behind a proposed new treatment for anxiety disorders.

The National Institute of Mental Health grant will provide $423,000 over the next three years to Dr. Christa McIntyre-Rodriguez and Dr. Sven Kroener to fund their research.
Diabetes Drug Shows Promise for Chronic Pain
Scientists seeking an effective treatment for one type of chronic pain believe a ubiquitous, generic diabetes medication might solve both the discomfort and the mental deficits that go with the pain.

“People who are in constant pain have problems thinking straight sometimes. The longer you’re in pain, the more entrenched the impairment becomes,” said Stephanie Shiers, a fourth-year cognition and neuroscience doctoral student at The University of Texas at Dallas and lead author of a study recently published in the Journal of Neuroscience. “These impairments aren’t addressed by existing therapeutics.”

In the study, UT Dallas researchers show how a type of chronic pain called neuropathic pain responds to metformin, one of the most prescribed medications worldwide, as well as to pain relievers gabapentin and clonidine.