Lee’s research focuses on using chemistry-based approaches and technologies to address challenging problems in biology and medicine. His work on the intricacies of interactions among proteins, for example, has applications to better understanding how protein malfunctions contribute to neurodegenerative diseases such as Alzheimer’s and spinocerebellar ataxia. “Understanding protein-protein interaction is very important for biology, medicine and drug discovery,” Lee said. “However, current technologies are limited. They give us static information about protein interaction, but what we need is to track how proteins behave in real-time, throughout the protein’s lifetime. “I’m developing chemistry-based technology for this kind of study, which hopefully will allow us to develop new drugs that maximize potency while minimizing side effects,” said Lee, who is co-inventor on three patents.
The Cancer Prevention and Research Institute of Texas (CPRIT) recently awarded a grant to Dr. Jiyong Lee
, assistant professor of chemistry at The University of Texas at Dallas, for research that may lead to more effective treatments for breast cancer and methods to prevent its recurrence in patients.
grant of $194,500 will support research aimed at identifying biological targets on breast cancer stem cells that might be susceptible to novel tumor-suppressing drugs.
Researchers at The University of Texas at Dallas have devised a new technique to isolate aggressive cells thought to form the root of many hard-to-treat metastasized cancers — a significant step toward developing new drugs that might target these cells.
“Our lab is interested in finding ways to prevent cancer recurrence,” said Dr. Jiyong Lee
, assistant professor in the Department of Chemistry and Biochemistry in the School of Natural Sciences and Mathematics
at UT Dallas. “The problem is, not all cancer cells are equal.