Jiyong Lee

Assistant Professor - Chemistry
The Lee Lab
Tags: Biochemistry and Chemical Biology Organic Chemistry

Professional Preparation

Post. Doc.
The Scripps Research Institute - 2012
UT Southwestern Medical Center - 2009
Yonsei University - 2001
Yonsei University - 1999


Isolation of Antagonists of Antigen-Specific Autoimmune T Cell Proliferation 2009 - Journal Article
Global and focused transcriptional profiling of small molecule aminopeptidase N inhibitor reveals its mechanism of angiogenesis inhibition 2008 - Journal Article
A general system for evaluating the efficiency of chromophore-assisted light inactivation (CALI) of proteins reveals Ru(ii) tris-bipyridyl as an unusually efficient “warhead” 2008 - Journal Article
Development of a new Ca2+/calmodulin antagonist and its anti-proliferative activity against colorectal cancer cells 2007 - Journal Article
Anti-tumor activity of N-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor 2007 - Journal Article
A New Synthesis Analogue of Thymidine, 7-(3-Bromo-phenoxy)-thymidine, Inhibits the Proliferation of Tumor Cells. 2005 - Journal Article
N-Hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity 2005 - Journal Article
A New Curcumin Derivative, HBC, Interferes with the Cell Cycle Progression of Colon Cancer Cells via Antagonization of the Ca2+/Calmodulin Function 2004 - Journal Article
The First Solid-Phase Synthesis of Oligomeric α-Aminooxy Peptides 2003 - Journal Article
Synthesis of Novel Glycopeptidomimetics ContainingO- andN-Glycosylated α-Aminooxy Acids by Fragment Coupling on Solid Support 2002 - Journal Article


Assistant Professor
University of Texas at Dallas [2012–Present]
Research Associate
The Scripps Research Institute [2009–2012]
Graduate Student Research Assistant
UT Southwestern [2005–2009]
Graduate Student
UT Southwestern [2005–2009]

News Articles

Professor Uses Chemistry and Protein Research to Battle Disease
Lee’s research focuses on using chemistry-based approaches and technologies to address challenging problems in biology and medicine. His work on the intricacies of interactions among proteins, for example, has applications to better understanding how protein malfunctions contribute to neurodegenerative diseases such as Alzheimer’s and spinocerebellar ataxia. “Understanding protein-protein interaction is very important for biology, medicine and drug discovery,” Lee said. “However, current technologies are limited. They give us static information about protein interaction, but what we need is to track how proteins behave in real-time, throughout the protein’s lifetime. “I’m developing chemistry-based technology for this kind of study, which hopefully will allow us to develop new drugs that maximize potency while minimizing side effects,” said Lee, who is co-inventor on three patents.
Grant Will Fund Team's Breast Cancer Work
The Cancer Prevention and Research Institute of Texas (CPRIT) recently awarded a grant to Dr. Jiyong Lee, assistant professor of chemistry at The University of Texas at Dallas, for research that may lead to more effective treatments for breast cancer and methods to prevent its recurrence in patients.
Lee’s CPRIT grant of $194,500 will support research aimed at identifying biological targets on breast cancer stem cells that might be susceptible to novel tumor-suppressing drugs.
University Scientists Isolate Cancer Stem Cells Using Novel Method
Researchers at The University of Texas at Dallas have devised a new technique to isolate aggressive cells thought to form the root of many hard-to-treat metastasized cancers — a significant step toward developing new drugs that might target these cells. 
“Our lab is interested in finding ways to prevent cancer recurrence,” said Dr. Jiyong Lee, assistant professor in the Department of Chemistry and Biochemistry in the School of Natural Sciences and Mathematics at UT Dallas. “The problem is, not all cancer cells are equal.