Jung-Whan Kim

Assistant Professor, Biological Sciences
Co-Director, Small Animal Imaging Core Facility
jay.kim@utdallas.edu
972-883-3502
BSB12.530
Jay Kim Lab
ORCID
Tags: Molecular Biology Cell Biology Cancer Metabolism Tumor Microenvironment Hypoxia Fibrosis Biology Biochemistry and Biophysics Pathobiology

Professional Preparation

Ph.D. - Cancer Biology
Johns Hopkins School of Medicine - 2006
D.V.M. - Veterinary Medicine
KonKuk University, Korea - 2000

Research Areas

Jay Kim lab is focused on understanding the heterogeneous metabolic signatures and targetable vulnerabilities in squamous cell carcinoma utilizing genetically engineered mouse models (GEMMs) and patient-derived xenograft (PDX) systems. Another major focus of our research is to understand the significance of hypoxic signaling and metabolic reprogramming of fibroblasts in cancer progression and fibrotic diseases.

Publications

Monitoring early tumor response to vascular targeted therapy using super-resolution ultrasound imaging 2017 - Conference Paper
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition 2017 - Journal Article
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity 2016 - Journal Article
NQO1 inhibits proteasome-mediated degradation of HIF-1α 2016 - Journal Article
Increased adipocyte O2consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity 2014 - Journal Article
Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1 2014 - Journal Article
Suppression of angiogenic response in local vein wall is associated with reduced thrombus resolution 2014 - Journal Article
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression 2013 - Journal Article
HIF isoforms in the skin differentially regulate systemic arterial pressure 2013 - Journal Article
Loss of fibroblast HIF-1α accelerates tumorigenesis 2012 - Journal Article

Appointments

Assistant Professor
University of Texas at Dallas [2013–Present]
Postdoctoral Fellow
University of California San Diego / Salk Institute [2008–2013]
Research Fellow
University of Pennsylvania [2000–2002]

Awards

Lung Cancer Discovery Award - American Lung Association [2016]
I M Rosenzweig Young Investigator Award - Pulmonary Fibrosis Foundation [2014]
Symposia Scholarship - Keystone Symposia [2012]
NRSA F32 Post-doctoral Fellowship - NIH/NCI [2011]
NRSA T32 Post-doctoral Fellowship - NIH/NCI [2010]
Symposia Scholarship - Keystone Symposia [2006]
Pathology Young Investigator Award - Johns Hopkins School of Medicine [2004]
Pre-doctoral Fellowship - Howard Hughes Medical Institute (HHMI) [2003]

Projects

Elucidating and Targeting the Glycolytic Reliance of Lung Squamous Cell Carcinoma
Lung cancer is a leading cause of cancer related death and has a higher mortality rate than colorectal, breast, and prostate cancers combined. Lung squamous cell carcinoma (SqCC), a subtype of lung cancer, accounts for 25-30% of all lung cancers. Although much research into lung cancer and possible treatments are being investigated, lung SqCC has benefited very little from the application of targeted therapeutic options, as a result, decades old platinum-based chemotherapy regiments remain the first-line treatment options. Therefore, identification of targetable vulnerabilities in lung SqCC is imperative to improve therapeutic outcome of lung SqCC patients.  There is an increasing body of evidence arguing for substantial heterogeneity in how individual cancers utilize glucose in promoting tumorigenesis. We recently reported that lung SqCC exhibits distinctively elevated GLUT1 expression resulting in high susceptibility to glycolytic inhibition whereas lung adenocarcinoma (ADC) is significantly less reliant on glucose and thereby resistant to glycolytic inhibition. Our group is focused on elucidating the molecular mechanisms underlying this previously unrecognized GLUT1-mediated glucose metabolism in lung squamous cancers. Targeting cancer glycolysis, on the assumption that glycolytic metabolism is uniformly elevated in most human cancers, has proven to be clinically unsatisfactory. Our discovery of distinct and exceptional glycolytic signature and glucose reliance phenotypically linked to lung SqCC argue that lung SqCC can be uniquely vulnerable to glucose restriction.
Tumor-associated Stromal Cells within the Hypoxic Tumor Microenvironment
The tumor microenvironment is comprised of host stromal cells, soluble growth factors and extracellular matrix that plays a critical role for virtually all tumorigenic processes. Tumor-associated stromal alterations are integral components of the tumor microenvironment that contribute to tumor growth and progression. Among many cellular populations, stromal fibroblasts are prominent cell populations of the tumor microenvironment and have been implicated in the development of various cancers including breast and pancreatic cancers. Unlike stromal cells residing in normal tissue, tumor-associated fibroblasts exhibit distinctive tumor-promoting features: they contribute to tumor cell proliferation, inflammation, angiogenesis, invasion and metastatic dissemination.​​In particular, my laboratory is interested in the mechanisms underlying the effects of stromal hypoxic signaling in tumorigenesis, angiogenesis and remodeling of the tumor microenvironment. The remodeling response to hypoxia is controlled primarily by hypoxia-inducible transcription factors (HIFs) 1 and 2, and the negative regulator of HIFs, von Hippel Lindau protein (VHL). We employ transgenic animal models in which the hypoxic response has been genetically ablated via deletion of VHL, HIFs and their target genes in various stromal components including fibroblasts in various tumor models to better understand the relationship of tumor-associated fibroblasts to tumor progression in the context of the hypoxic tumor microenvironment.
Metabolic Targeting of Fibrotic Diseases
Pulmonary fibrosis, scarring of the lungs caused by many conditions such as infections, environmental agents, and certain medications, is a ultimately fatal progressive disease with not only limited treatment options but also a poor prognosis and a survival expectancy of less than five years. Furthermore, idiopathic pulmonary fibrosis, the most common form of the disease, has no known cause. Therefore, it is crucial that mechanisms underlying pulmonary fibrosis progression be elucidated.​The presence of myofibroblasts in the animal models of pulmonary fibrosis as well as patients with lung fibrosis has been well documented in the current literature. Furthermore, myofibroblasts, which are responsible for the deposition of the matrix that constitutes the scar, have been found to play integral roles in the pathogenesis of this disease. During fibrotic progression, myofibroblast differentiation of pulmonary fibroblasts is a major process that facilitates the progression, migration, and secretion of extracellular matrix and collagen. In my lab, we are currently investigating the glycolytic reprogramming of fibroblasts that is crucial in fibroblast to myofibroblast differentiation utilizing in vitro culture as well as animal models in order to identify novel therapeutic targets.

News Articles

Researchers Receive $4.5 Million in Funding for Cancer Projects
More than $4.5 million in new funding from state and federal agencies will support cancer-related research over the next five years at The University of Texas at Dallas.

Two projects related to brain cancer, each totaling $200,000 over two years, recently received High-Impact/High-Risk Research Awards from the Cancer Prevention & Research Institute of Texas (CPRIT). A third CPRIT grant, of nearly $3.6 million over five years, will be used to establish a new core imaging facility for preclinical research. That award will be combined with $400,000 in matching funds from the University.

The Department of Defense (DOD) also recently awarded the University more than $527,000 for lung cancer research.
Scientists' Study Sweetens Connection Between Cancer, Sugar
In a new study, scientists at The University of Texas at Dallas have found that some types of cancers have more of a sweet tooth than others.

“It has been suspected that many cancer cells are heavily dependent on sugar as their energy supply, but it turns out that one specific type — squamous cell carcinoma — is remarkably more dependent,” said Dr. Jung-whan “Jay” Kim, assistant professor of biological sciences in the School of Natural Sciences and Mathematics and senior author of the study published online May 26 in the journal Nature Communications.
Scientists Discover New Cancer Connection Between Enzymes
A biologist at The University of Texas at Dallas and his colleagues have discovered that two enzymes previously linked independently with keeping cancer cells alive actually work in tandem to spur tumor growth.
“There has been no reason to suspect these two proteins interact, but now we know they do. This finding was totally unexpected,” said Dr. Jung-Whan (Jay) Kim, assistant professor of biological sciences and co-lead author of the study published online Dec. 14 in the journal Nature Communications.
Scientist Finds Clearer Obesity, Diabetes Link
New findings about the biological links between obesity and insulin resistance and Type 2 diabetes may also shed light on the connection between obesity and cancer, says a scientist at The University of Texas at Dallas.
In a study published in the journal Cell, UT Dallas’ Dr. Jung-whan Kim and colleagues at the University of California, San Diego found that a protein called HIF-1 alpha plays a key role in the development of insulin resistance and Type 2 diabetes in obese mice.
University Work Earns Talented Teen A Trip to Intel Science Contest
Two summers and many late nights devoted to research in a UT Dallas laboratory have earned one high school student a trip to Washington, D.C., to compete for honors among the nation’s elite young scientists. 

Joshua Choe, a senior at St. Mark’s School of Texas in Dallas, is one of 40 high school students chosen as finalists in the prestigious Intel Science Talent Search, the nation’s oldest pre-college science and math competition. Choe is the only finalist from Texas for the competition, which will be March 10-16 and present more than $1 million in awards. 

Activities

Journal Editorial Board
BMB Report
Journal Ad-hoc Reviewer
Science Translational Medicine
Cancer Research
Molecular Cancer Research
International Journal of Cancer
EBioMedicine
FEBS Letters
Scientific Reports
BMC Cancer
PLOS One
Molecular and Cellular Endocinology
Oncology Reports
Biochemistry and Cell Biology
Grant Ad-hoc Reviewer
The Academy of Medical Sciences Newton Advanced Fellowship, UK
French National Cancer Institute (INCa), France
Alan B. Slifka Foundation
Alaska INBRE Pilot Research Project
Breast Cancer Now, UK
State of Florida Department of Health

Affiliations

American Association for Cancer Research (AACR)
Active Member (2002 - present)
American Thoracic Society (ATS)
Full Member (2017 - present)

Funding

5P50CA70907 (PI: Minna, Career Enhancement Program PI: Kim)
- NIH/NCI Lung Cancer SPORE (UTSW/MD Anderson) [2016/09–2018/12]
Distinct Glycolytic Phenotypes of Lung Squamous Cell Carcinoma Dictate Selective Vulnerability to HIF-1/GLUT1 Inhibition
RP160617 (PI: Zhang, Co-Investigator: Kim)
- Cancer Prevention and Research Institute of Texas (CPRIT) Individual Investigator Award [2016/03–2019/02]
Optimizing Therapeutic Strategies against Lung Cancer using Multi-Modality Imaging
PFF-310063 (PI, Kim)
- Pulmonary Fibrosis Foundation I M Rosenzweig Young Investigator Award [2014/07–2016/06]
Evaluation of Hypoxia-inducible Factor-1 Signaling as Anti-Fibrotic Therapy