Tae Hoon Kim

Department Head
Associate Professor - Biological Sciences
Tags: Biology Genomics, Systems and Computational Biology Functional Genomics Epigenetics Transcriptional Regulation Innate Immunity Chronic Pain Cancer Genomics ChIP-seq GRO-seq HiC Single Cell Genomics lncRNA biology Enhancer Mechanisms

Professional Preparation

Ph.D. - Biochemistry
Harvard University
M.A. - Molecular and Cellular Biology
Harvard University
B.A. - Biology
Reed College

Research Areas

My laboratory has a broad and deep interest in understanding nuclear processes and mechanisms that segregate, fold and unfold chromosome fibers and disease causing changes that disrupt normal location, arrangement and interpretation of the human genome. Over the past decade and half, we have made seminal discoveries regarding active and poised promoters; sequence determinants of insulator protein CTCF occupancy and evolution; developmentally regulated looping of chromosomes in the human genome; and transcription elongation control mechanisms by innovating and disseminating new functional genomics techniques and approaches. Through close collaborations, we have also uncovered new insights into cis-regulatory architectures of several critical regulators of development and disease. We are leveraging our expertise in functional genomics to investigate diverse aspects of human health and disease ranging from innate immunity to chronic pain.

Publications

Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-beta enhanceosome in vitro. 1998 - Journal Article
Structure and function of the interferon-beta enhanceosome. 1998 - Journal Article

Appointments

Department Head
The University of Texas at Dallas [2019–Present]
Department of Biological Sciences
Associate Professor
The University of Texas at Dallas [2014–Present]
Department of Biological Sciences
Associate Professor
Yale University [2013–2014]
Department of Genetics
Assistant Professor
Yale University [2006–2013]
Department of Genetics
Postdoctoral Fellow
University of California at San Diego [2002–2006]
Ludwig Institute for Cancer Research
Teaching Fellow
Harvard University [1998–2002]
Department of Molecular and Cellular Biology

Awards

Stewart Trust Scholar Award (Pew-Stewart Scholar Award) - [2011]
Sidney Kimmel Scholar Award - [2008]
Rita Allen Scholar Award - [2007]
AACR Edward A. Smuckler Memorial Workshop Scholarship - [2006]
Korean American Scientists and Engineers Association Young Investigator Award - [2006]
James Kerr Award, Ludwig Institute for Cancer Research, San Diego, CA - [2005]
Selected Participant of International Workshop on Encoding Information in DNA Sequences in Japan - [2005]
Selected Participant of Frontiers of Human Embryonic Stems Cells - [2005]
Ruth L. Kirschstein National Research Service Award - [2004]
Distinction in Teaching Award, Harvard University - [2002]

News Articles

Where Does Chronic Pain Begin? Scientists Close In on Its Origins
A new study by researchers at The University of Texas at Dallas, UT MD Anderson Cancer Center, UT Health Science Center at Houston and Baylor College of Medicine has produced evidence of the source of chronic pain in humans, revealing several new targets for pain treatment.
The paper — published March 19 in Brain, one of the world’s oldest neurology journals — examined specialized nerve cells clustered near the base of the spine. Researchers took advantage of an exceedingly rare opportunity to study these nerves, called dorsal root ganglia (DRG), removed from cancer patients undergoing surgery at MD Anderson.