Tae Hoon Kim

Department Head
Associate Professor - Biological Sciences
Tags: Biology Genomics, Systems and Computational Biology Functional Genomics Epigenetics Transcriptional Regulation Innate Immunity Chronic Pain Cancer Genomics ChIP-seq GRO-seq HiC Single Cell Genomics lncRNA biology Enhancer Mechanisms

Professional Preparation

Ph.D. - Biochemistry
Harvard University
M.A. - Molecular and Cellular Biology
Harvard University
B.A. - Biology
Reed College

Research Areas

My laboratory has a broad and deep interest in understanding nuclear processes and mechanisms that segregate, fold and unfold chromosome fibers and disease causing changes that disrupt normal location, arrangement and interpretation of the human genome. Over the past decade and half, we have made seminal discoveries regarding active and poised promoters; sequence determinants of insulator protein CTCF occupancy and evolution; developmentally regulated looping of chromosomes in the human genome; and transcription elongation control mechanisms by innovating and disseminating new functional genomics techniques and approaches. Through close collaborations, we have also uncovered new insights into cis-regulatory architectures of several critical regulators of development and disease. We are leveraging our expertise in functional genomics to investigate diverse aspects of human health and disease ranging from innate immunity to chronic pain.

Publications

From sextant to GPS: twenty-five years of mapping the genome with ChIP. 2009 - Journal Article
ChIP-chip for genome-wide analysis of protein binding in mammalian cells. 2007 - Journal Article
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. 2007 - Journal Article
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. 2007 - Journal Article
Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells. 2006 - Journal Article
An all-round view of eukaryotic transcription. 2006 - Journal Article
Genome-wide analysis of protein-DNA interactions. 2006 - Journal Article
A high-resolution map of active promoters in the human genome. 2005 - Journal Article
Direct isolation and identification of promoters in the human genome. 2005 - Journal Article
beta-Catenin activates the growth factor endothelin-1 in colon cancer cells. 2005 - Journal Article

Appointments

Department Head
The University of Texas at Dallas [2019–Present]
Department of Biological Sciences
Associate Professor
The University of Texas at Dallas [2014–Present]
Department of Biological Sciences
Associate Professor
Yale University [2013–2014]
Department of Genetics
Assistant Professor
Yale University [2006–2013]
Department of Genetics
Postdoctoral Fellow
University of California at San Diego [2002–2006]
Ludwig Institute for Cancer Research
Teaching Fellow
Harvard University [1998–2002]
Department of Molecular and Cellular Biology

Awards

Korea Times Scholar - [1990]
Finalist, 49th Westinghouse Science Talent Search - [1990]

News Articles

Where Does Chronic Pain Begin? Scientists Close In on Its Origins
A new study by researchers at The University of Texas at Dallas, UT MD Anderson Cancer Center, UT Health Science Center at Houston and Baylor College of Medicine has produced evidence of the source of chronic pain in humans, revealing several new targets for pain treatment.
The paper — published March 19 in Brain, one of the world’s oldest neurology journals — examined specialized nerve cells clustered near the base of the spine. Researchers took advantage of an exceedingly rare opportunity to study these nerves, called dorsal root ganglia (DRG), removed from cancer patients undergoing surgery at MD Anderson.