Tae Hoon Kim

Associate Professor - Biological Sciences
Tags: Biology Genomics, Systems and Computational Biology Functional Genomics Epigenetics Transcriptional Regulation Innate Immunity Chronic Pain Cancer Genomics ChIP-seq GRO-seq HiC Single Cell Genomics lncRNA biology Enhancer Mechanisms

Professional Preparation

Ph.D. - Biochemistry
Harvard University - 2002
M.A. - Molecular and Cellular Biology
Harvard University - 2000
B.A. - Biology
Reed College - 1994

Research Areas

My laboratory has a broad and deep interest in undertanding nuclear processes and mechanisms that segregate, fold and unfold chromosome fibers and disease causing changes that disrupt normal location, arrangement and interpretation of the human genome. Over the past decade and half, we have made seminal discoveries regarding active and poised promoters; sequence determinants of insulator protein CTCF occupancy and evolution; developmentally regulated looping of chromosomes in the human genome; and transcription elongation control mechanisms by innovating and disseminating new functional genomics techniques and approaches. Through close collaborations, we have also uncovered new insights into cis-regulatory architectures of several critical regulators of development and disease. We are leveraging our expertise in functional genomics to investigate diverse aspects of human health and disease ranging from innate immunity to chronic pain.

Publications

Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome. 2017 - Journal Article
Chromosome Conformation Capture for Research on Innate Antiviral Immunity. 2017 - Journal Article
Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves 2016 - Journal Article
Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma 2016 - Journal Article
Histone Deacetylases Positively Regulate Transcription through the Elongation Machinery. 2015 - Journal Article
Boundary Associated Long Noncoding RNA Mediates Long-Range Chromosomal Interactions. 2015 - Journal Article
E-MTAB-3626 - Global run-on sequencing (GRO-seq) of human breast cancer cells treated with different drugs to perturb transcription elongation regulators 2015 - Data Set
E-MTAB-3631 - ChIP-seq of elongation factors in human breast cancer cells upon HDAC inhibition 2015 - Data Set
A novel virus-inducible enhancer of the interferon-β gene with tightly linked promoter and enhancer activities. 2014 - Journal Article
Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells. 2014 - Journal Article

Appointments

Associate Professor
The University of Texas at Dallas [2014–Present]
Department of Biological Sciences
Associate Professor
Yale University [2013–2014]
Department of Genetics
Assistant Professor
Yale University [2006–2013]
Department of Genetics
Postdoctoral Fellow
University of California at San Diego [2002–2006]
Ludwig Institute for Cancer Research
Teaching Fellow
Harvard University [1998–2002]
Department of Molecular and Cellular Biology

Awards

Stewart Trust Scholar Award (Pew-Stewart Scholar Award) - [2011]
Sidney Kimmel Scholar Award - [2008]
Rita Allen Scholar Award - [2007]
AACR Edward A. Smuckler Memorial Workshop Scholarship - [2006]
Korean American Scientists and Engineers Association Young Investigator Award - [2006]
James Kerr Award, Ludwig Institute for Cancer Research, San Diego, CA - [2005]
Selected Participant of International Workshop on Encoding Information in DNA Sequences in Japan - [2005]
Selected Participant of Frontiers of Human Embryonic Stems Cells - [2005]
Ruth L. Kirschstein National Research Service Award - [2004]
Distinction in Teaching Award, Harvard University - [2002]