Tae Hoon Kim

Department Head
Associate Professor - Biological Sciences
Tags: Biology Genomics, Systems and Computational Biology Functional Genomics Epigenetics Transcriptional Regulation Innate Immunity Chronic Pain Cancer Genomics ChIP-seq GRO-seq HiC Single Cell Genomics lncRNA biology Enhancer Mechanisms

Professional Preparation

Ph.D. - Biochemistry
Harvard University
M.A. - Molecular and Cellular Biology
Harvard University
B.A. - Biology
Reed College

Research Areas

My laboratory has a broad and deep interest in understanding nuclear processes and mechanisms that segregate, fold and unfold chromosome fibers and disease causing changes that disrupt normal location, arrangement and interpretation of the human genome. Over the past decade and half, we have made seminal discoveries regarding active and poised promoters; sequence determinants of insulator protein CTCF occupancy and evolution; developmentally regulated looping of chromosomes in the human genome; and transcription elongation control mechanisms by innovating and disseminating new functional genomics techniques and approaches. Through close collaborations, we have also uncovered new insights into cis-regulatory architectures of several critical regulators of development and disease. We are leveraging our expertise in functional genomics to investigate diverse aspects of human health and disease ranging from innate immunity to chronic pain.

Publications

Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons. 2019 - Journal Article
Global transcriptional activity dynamics reveal functional enhancer RNAs 2018 - Journal Article
Time course ChIP-seq analysis of the human GM12878 lymphoblasts upon Sendai Virus infection 2018 - Data Set
Time course GRO-seq analysis of the human GM12878 lymphoblasts upon Sendai Virus infection 2018 - Data Set
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling. 2018 - Journal Article
3C-Based Chromatin Interaction Analyses. 2018 - Journal Article
4C Analysis of 3C, ChIP-Loop, and Control Libraries. 2018 - Journal Article
5C Analysis of 3C, ChIP-Loop, and Control Libraries. 2018 - Journal Article
Polymerase Chain Reaction (PCR) Detection of 3C Ligation Products Present in 3C, ChIP-Loop, and Control Libraries: Library Titration and Interaction Frequency Analysis. 2018 - Journal Article
Generation of 3C Libraries from Cross-Linked Cells. 2018 - Journal Article

Appointments

Department Head
The University of Texas at Dallas [2019–Present]
Department of Biological Sciences
Associate Professor
The University of Texas at Dallas [2014–Present]
Department of Biological Sciences
Associate Professor
Yale University [2013–2014]
Department of Genetics
Assistant Professor
Yale University [2006–2013]
Department of Genetics
Postdoctoral Fellow
University of California at San Diego [2002–2006]
Ludwig Institute for Cancer Research
Teaching Fellow
Harvard University [1998–2002]
Department of Molecular and Cellular Biology

Awards

Korea Times Scholar - [1990]
Finalist, 49th Westinghouse Science Talent Search - [1990]

News Articles

Where Does Chronic Pain Begin? Scientists Close In on Its Origins
A new study by researchers at The University of Texas at Dallas, UT MD Anderson Cancer Center, UT Health Science Center at Houston and Baylor College of Medicine has produced evidence of the source of chronic pain in humans, revealing several new targets for pain treatment.
The paper — published March 19 in Brain, one of the world’s oldest neurology journals — examined specialized nerve cells clustered near the base of the spine. Researchers took advantage of an exceedingly rare opportunity to study these nerves, called dorsal root ganglia (DRG), removed from cancer patients undergoing surgery at MD Anderson.