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Ph.D. - Biochemistry Harvard University
M.A. - Molecular and Cellular Biology Harvard University
B.A. - Biology Reed College
My laboratory has a broad and deep interest in understanding nuclear processes and mechanisms that segregate, fold and unfold chromosome fibers and disease causing changes that disrupt normal location, arrangement and interpretation of the human genome. Over the past decade and half, we have made seminal discoveries regarding active and poised promoters; sequence determinants of insulator protein CTCF occupancy and evolution; developmentally regulated looping of chromosomes in the human genome; and transcription elongation control mechanisms.We innovate and disseminate new functional genomics frameworks, techniques and approaches. Through close collaborations, we have also uncovered new insights into cis-regulatory architectures of several critical regulators of development and diseases. We are leveraging our expertise in functional genomics to investigate diverse aspects of human health and disease ranging from innate immunity to chronic pain.
Oxidative Stress and the Intersection of Oncogenic Signaling and Metabolism in Squamous Cell Carcinomas 2021 - Journal Article
YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling 2020 - Data Set
YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling. 2020 - Journal Article
The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway. 2020 - Journal Article
Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons. 2019 - Journal Article
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. 2019 - Journal Article
GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126. 2019 - Journal Article
A new study by researchers at The University of Texas at Dallas, UT MD Anderson Cancer Center, UT Health Science Center at Houston and Baylor College of Medicine has produced evidence of the source of chronic pain in humans, revealing several new targets for pain treatment. The paper — published March 19 in Brain, one of the world’s oldest neurology journals — examined specialized nerve cells clustered near the base of the spine. Researchers took advantage of an exceedingly rare opportunity to study these nerves, called dorsal root ganglia (DRG), removed from cancer patients undergoing surgery at MD Anderson.