Eberhard Voit

Clinical Professor - Biological Sciences

My research interests lie in the field of complex biomedical systems, with a particular focus on metabolic pathway systems analysis, and the development of the modeling framework of Biochemical Systems Theory.

404-731-1736
ORCID

Professional Preparation

Dr. rer. nat. (Ph.D.) - Developmental and Theoretical Biology
Universität zu Köln - 1981

Staatsexamen (M.S.) - Mathematics
Universität zu Köln - 1978

Diplom (M.S.) - Biology
Universität zu Köln - 1976

Research Areas

Systems Biology

Voit’s research interests lie in the field of biomedical systems analysis, with a particular focus on metabolic pathway systems. In addition to over 300 full-length articles and book chapters, mostly on systems analysis, computational biostatistics and science education, Voit has authored, co-authored, and edited six books on the subject of biological systems. Over the years, he has been directing a diverse lab dedicated to developing and utilizing a wide spectrum of mathematical and computational methodologies and tools, including dynamic, discrete, probabilistic, and bioinformatics models. In applications, his lab has addressed a variety of biomedical phenomena pertaining to metabolic and physiological systems, signaling systems, specific diseases and infections, issues of personalized medicine and predictive health, cell populations with heterogeneous characteristics, microbial communities, biomedical systems exposed to unpredictable or chaotic inputs, as well as exposure assessment and environmental health. Throughout his career, the education of emerging systems biologists and the general public has been of great importance to Voit, and his books and tutorials have addressed readers with different levels of expertise, from high schoolers and the lay population to undergraduates, graduate students and colleagues. Two of his books have been translated into Chinese and one into Korean. One book is currently being translated into Chinese and Greek.

Publications

Ayalew, M., B.W. Mwaura, C.M. Kumbale, C. Rono, N. Torres-Patarroyo, T. Vlčko, L. Ohnoutková, E.O. Voit: A new model for xylem loading and long-distance transport of iron explains the effect of kanamycin on metal uptake in Arabidopsis. Front. Plant Sci., Volume 14 https://doi.org/10.3389/fpls.2023.1147598 2023 - publications

Olivença, D.V., J.D. Davis, Voit, E.O.: Inference of dynamic interaction networks: A comparison between Lotka-Volterra and multivariate autoregressive models. Front. Bioinf. (Expert Opin. Network Bioinf.) 2:1021838. 2022 - publications

Dalvi-Garcia, F., L. L. Fonseca, A. T. Ribeiro de Vasconcelos, C. Hedin-Pereira, and E. O. Voit. Cortisol and the dopaminergic and serotonergic-kynurenine pathways interact in the etiology of depression. PLOS Comp. Biol., 17(5): e1008956. 2021 - publications

Voit, E.O.: Systems Biology. A Very Short Introduction. Oxford University Press, Oxford, U.K. 2020 - publications

Davis, J.D., Kumbale, C.M., Zhang, Q. and E.O. Voit: Dynamical systems approaches to personalized medicine. Curr. Opin. Biotechn. 58, 168-174. 2019 - publications

Voit, E.O.: Perspective: Dimensions of the Scientific Method. PLoS Comp. Biol. 15(9): e1007279. 2019 - publications

Voit, E.O.: A First Course in Systems Biology. Second Edition, Garland Science, New York, NY. 2017 - publications

Voit, E.O.: The Inner Workings of Life. Vignettes in Systems Biology, xii + 210 pp., Cambridge University Press, Cambridge, U.K. 2016 - publications

Awards

Professor Emeritus - Georgia Institute of Technology [2024]

Notable Alumnus - University of Cologne [2023]

Sigma Xi Sustained Research (Lifetime Achievement) - Sigma Xi [2021]

Outstanding Bioengineering Advisor - Georgia Institute of Technology [2021]

Thank-a-Teacher Award - Georgia Institute of Technology [2020]

Fellow - Society of Mathematical Biology [2018]

Overseas Fellow - the Royal Society of Medicine, United Kingdom [2018]

Class of 1934 Outstanding Interdisciplinary Activities Award - Georgia Institute of Technology [2016]

Howard Hughes Professorship Semifinalist - HHMI [2014]

Fellow - American Association for the Advancement of Science [2012]

Projects

Effect of Dioxin on Human Health

Humans are constantly exposed to lipophilic persistent organic pollutants (POPs) that accumulate in fatty foods. Among the numerous POPs, dioxins, in particular 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), can impact several organ systems. In this study, we develop a multiscale computational approach to assess the effects of TCDD on human health, using a “template-and-anchor” (T&A) structure. In this approach, a template is a high-level umbrella model that permits the integration of information from various, detailed anchor models.