Skip to main content
Eberhard Voit

Eberhard Voit

Clinical Professor - Biological Sciences
Regents' Professor Emeritus, Georgia Institute of Technology

My research interests lie in the field of complex biomedical systems, with a particular focus on metabolic pathway systems analysis, and the development of the modeling framework of Biochemical Systems Theory.

 
404-731-1736
ORCID

Professional Preparation

Dr. rer. nat. (Ph.D.) - Developmental and Theoretical Biology
Universität zu Köln - 1981
Staatsexamen (M.S.) - Mathematics
Universität zu Köln - 1978
Diplom (M.S.) - Biology
Universität zu Köln - 1976

Research Areas

Systems Biology
Voit’s research interests lie in the field of biomedical systems analysis, with a particular focus on metabolic pathway systems. In addition to over 300 full-length articles and book chapters, mostly on systems analysis, computational biostatistics and science education, Voit has authored, co-authored, and edited six books on the subject of biological systems. Over the years, he has been directing a diverse lab dedicated to developing and utilizing a wide spectrum of mathematical and computational methodologies and tools, including dynamic, discrete, probabilistic, and bioinformatics models. In applications, his lab has addressed a variety of biomedical phenomena pertaining to metabolic and physiological systems, signaling systems, specific diseases and infections, issues of personalized medicine and predictive health, cell populations with heterogeneous characteristics, microbial communities, biomedical systems exposed to unpredictable or chaotic inputs, as well as exposure assessment and environmental health. Throughout his career, the education of emerging systems biologists and the general public has been of great importance to Voit, and his books and tutorials have addressed readers with different levels of expertise, from high schoolers and the lay population to undergraduates, graduate students and colleagues. Two of his books have been translated into Chinese and one into Korean. One book is currently being translated into Chinese and Greek. 

Publications

Hassler, H.B., A.M. Seekatz, G. Drew, M.L. Kemp, and E.O. Voit: Dynamic model sheds lght on the etiology, progression, and fecal microbiota transplant treatment of C. difficile infection. 2026 - in revision
Voit, E.O.: Systems biology can provide guidance to synthetic biology in the pursuit of new drug targets. Front. Pharmacol. Volume 17 - 2026 | https://doi.org/10.3389/fphar.2026.1770107 2026 - publication
Voit, E.O.: Format-preserving reduction of canonical nonlinear models. Bull. Math. Biol. 88, 49. https://doi.org/10.1007/s11538-026-01599-2, 2026. 2026 - publication
Kumbale, C.M., Q. Zhang, and E.O. Voit: Analysis of Systemic Effects of dioxin on human health through template-and-anchor modeling. PLOS Comp. Biol., 21(3): e1012840. https://doi.org/10.1371/journal.pcbi.1012840, 2024. 2024 - publication
Goss, S. A., Steininger, R. J., Narayanan, D., Olivença, D. V., Sun, Y., Qiu, P., Amato, J., Voit, E. O., Voit, W. E., and E. J. Kildebeck: Polycraft World AI Lab (PAL): An extensible platform for evaluating artificial intelligence agents. arXiv. https://doi.org/10.48550/arXiv.2301.11891, 2023. 2023 - publication
Kumbale, C.M., Q. Zhang, and E.O. Voit: Hepatic cholesterol biosynthesis and dioxin-induced dysregulation: A multiscale computational approach.Food Chem. Toxicol. 181, 114086, 2023; doi: 10.1016/j.fct.2023.114086. 2023 - publication
Voit, E.O., A.M. Shah, D.V. Olivenca, and Y. Vodovotz: What’s next for computational systems Biology?  Frontiers Sys. Biol., Frontiers Sys. Biol. 3, 2023; doi.org/10.3389/fsysb.2023.1250228. 2023 - publication
Ayalew, M., B.W. Mwaura, C.M. Kumbale, C. Rono, N. Torres-Patarroyo, T. Vlčko, L. Ohnoutková, E.O. Voit: A new model for xylem loading and long-distance transport of iron explains the effect of kanamycin on metal uptake in Arabidopsis. Front. Plant Sci., Volume 14 https://doi.org/10.3389/fpls.2023.1147598 2023 - publication

Awards

Textbook Excellence Award - Textbook and Academic Authors Association [2026]
Regents' Emeritus Professor - Georgia Institute of Technology [2024]
Notable Alumnus - University of Cologne [2023]
Lifetime Achievement Award - ScholarGPS [2022]
Sigma Xi Sustained Research (Lifetime Achievement) - Sigma Xi [2021]
Outstanding Bioengineering Advisor - Georgia Institute of Technology [2021]
Thank-a-Teacher Award - Georgia Institute of Technology [2020]
Fellow - Society of Mathematical Biology [2018]
Overseas Fellow - the Royal Society of Medicine, United Kingdom [2018]
Class of 1934 Outstanding Interdisciplinary Activities Award - Georgia Institute of Technology [2016]

Appointments

Clinical Professor
Biological Sciences, UT Dallas [2024–Present]
Professor and David D. Flanagan Chair in Biological Systems
Biomedical Engineering, Georgia Institute of Technology [2004–2024]
Associate / Full Professor
Biometry, Medical University of South Carolina [1986–2004]
Sabbatical Research Fellow
Cooperative Research Center for Forestry, Tasmania, Australia [1993–1994]
Research Assistant
Zoology, University of Cologne [1979–1986]

Projects

Effect of Dioxin on Human Health
Humans are constantly exposed to lipophilic persistent organic pollutants (POPs) that accumulate in fatty foods. Among the numerous POPs, dioxins, in particular 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), can impact several organ systems. In this study, we develop a multiscale computational approach to assess the effects of TCDD on human health, using a “template-and-anchor” (T&A) structure. In this approach, a template is a high-level umbrella model that permits the integration of information from various, detailed anchor models.