Leonidas Bleris

Associate Professor - Bioengineering
Tags: Bioengineering Electrical Engineering Computer Engineering

Professional Preparation

PostDoc - Systems Biology
Harvard University - 2009
PhD - Electrical Engineering
Lehigh University - 2006
M.S. - Electrical and Computer Engineering
Lehigh University - 2002
BS - Electrical and Computer Engineering
Aristotle University of Thessaloniki - 2000


Modular and Scalable Logic Computation in Vivo With Transcription Factor Inputs. Leisner M., L. G. Bleris, J. Lohmueller, Z. Xie, Y. Benenson. Nature Nanotechnology 5, 666–670, 2010. 2010 - Publication
Logic Integration of mRNA Signals by an RNAi-based Molecular Computer. Xie, Z., S. J. Liu, L. G. Bleris, Y. Benenson. Nucleic Acids Research, 38(8):2692-701 2010 - Publication
A System-on-a-Chip Implementation for Embedded Real-Time Model Predictive Control. Vouzis, P. D., L. G. Bleris, M. G. Arnold, M. V. Kothare.IEEE Transactions on Control Systems Technology, 17:5, 1006-1017, 2009 2009 - Publication
Molecular Circuits for Information Processing in Human Cells. Bleris, L. G.Bio 24, 42-46, 2008 2008 - Publication
Pathways for Optimization-based Drug Delivery Systems and Devices. Bleris, L. G., P. D. Vouzis, J. G. Garcia, M. G. Arnold, M. V. Kothare.Control Engineering Practice, 15:10, 2007, 1280-1291 2007 - Publication
A universal RNAi-based logic evaluator that operates in mammalian cells. Rinaudo, K.*, L. G. Bleris*, R. Maddamsetti, S. Subramanian, R. Weiss, Y. Benenson. Nature Biotechnology 25, 795-801, 2007(*equal contribution) 2007 - Publication
Model Predictive Hydrodynamic Regulation of Microflows. Bleris, L. G., J. G. Garcia, M. G. Arnold., M. V. Kothare.Journal of Micromechanics and Microengineering, 16, 1792-1799, 2006 2006 - Publication
Towards Embedded Model Predictive Control for System-On-a-Chip Applications. Bleris, L. G., J. G. Garcia, M. V. Kothare, M. G. Arnold.Journal of Process Control, 16, 255-264, 2006 2006 - Publication
Low-Order Empirical Modeling of Distributed Parameter Systems Using Temporal and Spatial Eigenfunctions. Bleris, L. G. and M. V. Kothare.Computers & Chemical Engineering, 29, 817-827, 2005 2005 - Publication
Reduced Order Distributed Boundary Control of Thermal Transients in Microsystems. Bleris, L. G. and M. V. Kothare.IEEE Transactions on Control Systems Technology, 13:6, 853-867, 2005 2005 - Publication


Independent Expert/Evaluator
European Commission [2008–2018]


Engineering Synthetic Gene Networks in Cells, Tulane University
Gene Networks and Devices, Aristotle University of Thessaloniki
"Engineering Robust to Fluctuations General-Purpose Gene Networks", UT Southwestern Medical Center
Engineering in Cells: Synthetic Molecular Devices, RWTH University, Germany
A Universal RNAi-based Logic Evaluator that Operates in Mammalian Cells, Lehigh University

News Articles

2 UT Dallas Researchers Receive Awards from NSF CAREER Program
Two UT Dallas faculty members recently earned National Science Foundation Faculty Early Career Development (CAREER) Awards.
Dr. Anton Malko
, assistant professor of physics, and Dr. Leonidas Bleris, assistant professor of bioengineering, will each receive $400,000 in funding for five years of research into areas of renewable energy and genome editing technologies, respectively.
Malko’s award will advance his research in the development of new hybrid materials that could offer a versatile platform for optoelectronic applications. In particular, they show promise for the next generation of photovoltaic solar cells that will harness sunlight for use as an ecofriendly and renewable energy-generating technology.
Jonsson School Researchers Gain New Insight on Biological Networks
Bioengineers from the Erik Jonsson School of Engineering and Computer Science at UT Dallas have shed light on the mysteries of biological pathways.
The findings, which were published in the journal Proceedings of the National Academy of Sciences (PNAS), could affect a wide range of applications relevant to public health and therapeutics.

In the article, “Discriminating Direct and Indirect Connectivities in Biological Networks,” the team of researchers shows that the integration of engineering, mathematics and synthetic biology can lead to new insights on the properties of biological networks.
Team Creates New Approach to Gene Therapy
Bioengineers at The University of Texas at Dallas have created a novel gene-delivery system that shuttles a gene into a cell, but only for a temporary stay, providing a potential new gene-therapy strategy for treating disease.
The approach offers distinct advantages over other types of gene therapies under investigation, said Richard Taplin Moore MS’11, a doctoral student in bioengineering in the Erik Jonsson School of Engineering and Computer Science. He is lead author of a study describing the new technique in the Jan. 30 issue of the journal Nucleic Acids Research
Why Do Identical Cells Act Differently? Team Unravels Sources of Cellular ‘Noise’
University of Texas at Dallas researchers have taken an important step toward explaining why genetically identical cells can produce varying amounts of the same protein associated with the same gene.

In a study published Aug. 18 and appearing in the Sept. 18 print edition of the journal Nucleic Acids Research, researchers demonstrated that most of the fluctuations in gene expression between identical cells occur in the first step of protein production, called transcription.

Understanding why and how such fluctuations, or cellular noise, occur is a fundamental bioengineering problem, said Dr. Leonidas Bleris, associate professor of bioengineering in the Erik Jonsson School of Engineering and Computer Science and Fellow, Cecil H. and Ida Green Professor in Systems Biology Science.